Ethyl 2-(4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy)propanoate
Fenoxaprop-ethyl
CAS: 66441-23-4
Molecular Formula: C18H16ClNO5
Ethyl 2-(4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy)propanoate - Names and Identifiers
Ethyl 2-(4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy)propanoate - Physico-chemical Properties
| Molecular Formula | C18H16ClNO5 |
| Molar Mass | 361.78 |
| Density | 1.2523 (rough estimate) |
| Melting Point | 84-85° |
| Boling Point | bp 200° at 100 Pa |
| Specific Rotation(α) | -1～+1°(20℃/D)(c=1, 1,4-dioxane) |
| Flash Point | 242.6°C |
| Vapor Presure | 2.79E-09mmHg at 25°C |
| Appearance | neat |
| pKa | -0.08±0.30(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.6500 (estimate) |
| Physical and Chemical Properties | The appearance was a white solid. m. P. 84-85 °c, vapor pressure 1.9 x 10-6Pa (20 °c), 4.06 x 10-6Pa (40 °c). Soluble in acetone, toluene, ethyl acetate, soluble in ethanol, cyclohexane, octanol, difficult to dissolve in water (0.9mg/L,20 C). Storage at 50 ℃ for 6 months, stable to light, acid, alkali decomposition. |
| Use | For the control of soybean, cotton, sugar beet and other dicotyledonous crop fields annual, perennial monocotyledonous weeds |
Ethyl 2-(4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy)propanoate - Risk and Safety
| Risk Codes | R43 - May cause sensitization by skin contact R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R22 - Harmful if swallowed |
| Safety Description | S24 - Avoid contact with skin. S37 - Wear suitable gloves. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 2 |
| RTECS | UA2454000 |
| HS Code | 29349990 |
| Toxicity | LD50 in male, female rats (mg/kg): 2357, 2500 orally; 739, 864 i.p. (Bieringer) |
Ethyl 2-(4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy)propanoate - Upstream Downstream Industry
| Raw Materials | L(+)-Lactic acid Chlorine Urea Phosphorus pentachloride |
Ethyl 2-(4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy)propanoate - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| toxicity | Acute oral LD50 in rats was 2357-2500mg/kg, the acute oral LD50 of mice was 4670 ~ 5490mg/kg. Rabbit acute percutaneous LD50>1000mg/kg, male rats> 2000mg/kg. Mild irritation to eyes and skin. In mice subacute feeding Test No effect dose of 80 mg/kg feed. No teratogenicity and mutagenicity, no carcinogenic dose <1.58mg/kg in rats, 5.48mg/kg in mice. Toxic to fish, low toxicity to birds, high toxicity to bees. Blue gill fish lc500.31 mg/L (96H), acute oral quail LD50>2510mg/kg, Bee LD50>0.00002mg/only. |
| Use | heteroepoxy phenoxy fatty herbicide. For the control of soybean, sugar beet, cotton, potato, vegetables and other crops of annual and perennial grass weeds. Increasing the dosage can control perennial weeds. Spraying spring wheat with 0.42 ~ 0.6g active ingredient/100m2 can control and eliminate annual graminaceous weeds such as Wild Oats; Spraying winter wheat with 0.42 ~ 0.52g active ingredient/100m2 can control and eliminate annual graminaceous weeds such as maimian. Generally recommended dosage of 1.2~1.5g/100. used to control annual and perennial monocotyledonous weeds in fields of soybean, cotton, sugar beet and other dicotyledonous crops |
| production method | Preparation Method -2-(4-acetylphenoxy) preparation of ethyl propionate to a solution of 4-hydroxyacetophenone potassium salt (25g) in dimethylformamide (DMF) was added ethyl 2-chloropropionate (27.3g) over 30min under nitrogen, stir at 85-90 for 3H, remove KCl by filtration, remove DMF under reduced pressure, dissolve the product in ethyl acetate, extract with alkali and water, dry and concentrate to give 30g of 2-(4-acetylphenoxy) ethyl propionate. Preparation of ethyl 2-(4-acetoxyphenoxy) propanoate Peracetic acid (16%,15.61g,33.0mmol) was added at 58 °c, 8 × 10-3PA, 30min. Ethyl 2-(4-acetylphenoxy) propionate (5.01g,21.0mmol) in equilibrium with acetic acid (50ml) was added dropwise. The reaction was refluxed for 8H at 48-54 ° C. t 7 × 103-8 × 103Pa, cooled, and the acetic acid was removed under reduced pressure to give 5.34g of ethyl 2-(4-acetoxyphenoxy) propionate. Preparation of ethyl 2-(4-hydroxyphenoxy) propionate 2-(4-acetoxyphenoxy) propionate was prepared at 80 °c using 2 drops of ethanol (40ml) and concentrated hydrochloric acid. Ethyl propionate was refluxed for 2H for hydrolysis, and the reactants were concentrated under reduced pressure to give ethyl 2-(4-acetoxyphenoxy) propionate, which was refluxed for 2H for hydrolysis, and the reactants were concentrated under reduced pressure to give 2-(4-hydroxyphenoxy). Ethyl propionate (3.8g). Synthesis of oxazolylin 2g of potassium carbonate was added to a solution of ethyl 2-(4-hydroxyphenoxy) propionate (2.0g,9.8mmol) in acetonitrile (25ml) and refluxed for 1H. The reaction was cooled and 2, 6-dichlorobenzoxazole (10.2g, mmol) was added and the reaction was refluxed for 4H and concentrated to dryness. Acetonitrile (50ml) was added to the reaction mixture. Refluxing for 2H, hot filtration, concentration to 25ml, cooling to give oxazolylin 2.9g. Preparation Method 2 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:32:07
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Raw Materials for Ethyl 2-(4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy)propanoate